Preclinical and clinical findings suggest that tumor-specific immune responses may be
responsible–at least in part–for the clinical success of therapeutic regimens that rely on …

Most molecular hallmarks of cellular senescence have been identified in studies of cells
aged in vitro by driving them into replicative or stress-induced senescence. Comparatively …

Chemotherapy can reinstate anticancer immunosurveillance through inducing tumor
immunogenic cell death (ICD). Here, we show that anthracyclines and oxaliplatin can trigger …

ABSTRACT Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses
exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in …

It is estimated that 74,000 people in the United States and roughly 386,000 people globally
will be newly diagnosed with bladder cancer in 2015. 1, 2 Bladder cancer represents a …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

The search for immunostimulatory drugs applicable to cancer immunotherapy may profit
from target‐agnostic methods in which agents are screened for their functional impact on …

While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory
lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to …

Background The incidence of anal squamous cell carcinoma has been increasing markedly
in the past few decades. Currently, there is no validated treatment for advanced-stage anal …

Unscheduled increases in ploidy underlie defects in tissue function, premature aging, and
malignancy. A concomitant event to polyploidization is the amplification of centrosomes, the …