Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

[HTML][HTML] Naringenin: A flavanone with anti-inflammatory and anti-infective properties

J Cai, H Wen, H Zhou, D Zhang, D Lan, S Liu… - Biomedicine & …, 2023 - Elsevier
Although a growing body of research has recently shown how crucial inflammation and
infection are to all major diseases, several of the medications currently available on the …

Single-neuron neurodegeneration as a degenerative model for Parkinson's disease

S Huenchuguala, J Segura-Aguilar - Neural Regeneration …, 2024 - journals.lww.com
The positive effect of levodopa in the treatment of Parkinson's disease, although it is limited
in time and has severe side effects, has encouraged the scientific community to look for new …

miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease

SC Chan, CW Tung, CW Lin, YS Tung, PM Wu… - Free Radical Biology …, 2023 - Elsevier
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
accumulation of mutant Huntingtin protein (mHTT) and oxidative stress-induced neuronal …

Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson's disease

T He, X Lin, A Su, Y Zhang, Z Xing, L Mi… - Frontiers in …, 2023 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease worldwide,
often occurs in middle-aged and elderly individuals. The pathogenesis of PD is complex and …

Fagopyrum tataricum (L.) Gaertn interacts with Gsk-3β/Nrf-2 signalling to protect neurotoxicity in a zebrafish model

SN Rahmatkar, AK Rana, R Kumar, D Singh - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Fagopyrum tataricum (L.) Gaertn is used as a folk
medicine in many Asian countries due to its anti-inflammatory, antioxidant, and several other …

Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells

DK Sah, A Arjunan, SY Park, B Lee, YD Jung - Antioxidants, 2024 - mdpi.com
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally,
accounting for approximately 881,000 deaths each year. Traditional approaches such as …

Natural flavonoids as potential therapeutics in the management of Alzheimer's disease: a review

PT Nguyen-Thi, TK Vo, THT Pham, TT Nguyen… - 3 Biotech, 2024 - Springer
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder which is
associated with the accumulation of proteotoxic Aβ peptides, and pathologically …

Impact of NQO1 dysregulation in CNS disorders

L Yuhan, M Khaleghi Ghadiri, A Gorji - Journal of Translational Medicine, 2024 - Springer
Abstract NAD (P) H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation
of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress …

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Y Peng, R Qu, S Xu, H Bi, D Guo - Heliyon, 2024 - cell.com
Naringin is a natural flavonoid with therapeutic properties found in citrus fruits and an active
natural product from herbal plants. Naringin has become a focus of attention in recent years …