Bioprinting shows excellent potential for preclinical tumor modeling, with significant
advantages over 2D cell cultures in replicating the tumor microenvironment (TME). Recently …

Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …

Despite advances in treatment, lung cancer survival rates remain low. A better
understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts …

The advance of immunotherapy has shifted the paradigm of cancer management in clinics.
Nevertheless, a considerable subset of pancreatic ductal adenocarcinoma (PDAC) patients …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading
cause of cancer-related death. Hallmarks include desmoplasia with variable extracellular …

Solid tumors are complex entities that actively shape their microenvironment to create a
supportive environment for their own growth. Angiogenesis and immune suppression are …

Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is
known about how it predisposes the tissue microenvironment preceding tumor formation …

Introduction: The research on tumor microenvironment (TME) has recently been gaining
attention due to its important role in tumor growth, progression, and response to therapy …

Hypoxia is a common feature of solid tumours affecting their biology and response to
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …

Successful clinical methods for tumor elimination include a combination of surgical
resection, radiotherapy, and chemotherapy. Radiotherapy is one of the crucial components …