HIF-dependent mechanisms of relationship between hypoxia tolerance and tumor development

DS Dzhalilova, OV Makarova - Biochemistry (Moscow), 2021 - Springer
Oxygen deficiency is one of the key pathogenetic factors determining development and
severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of …

Hypoxia in lung cancer management: a translational approach

J Ancel, JM Perotin, M Dewolf, C Launois, P Mulette… - Cancers, 2021 - mdpi.com
Simple Summary Hypoxia is a common feature of lung cancers. Nonetheless, no guidelines
have been established to integrate hypoxia-associated biomarkers in patient management …

Associations Between Single Nucleotide Polymorphisms of Hypoxia-Related Genes and Capsule Formation in Hepatocellular Carcinoma

S Chen, Y Duan, Y Zhang, L Cheng, L Cai… - Journal of …, 2023 - Taylor & Francis
Purpose Tumor capsule is an independent prognostic factor for patients with hepatocellular
carcinoma (HCC) and used increasingly to guide clinical decision-making. Considering the …

Prediction of potential deleterious nonsynonymous single nucleotide polymorphisms of HIF1A gene: A computational approach

Z Jamali, M Taheri-Anganeh, M Entezam - Computational Biology and …, 2020 - Elsevier
Abstract Hypoxia-inducible factor-1α (HIF-1α) is the oxygen sensitive subunit of HIF1
transcription factor. Its variations is associated with several diseases including different type …

[HTML][HTML] Different polymorphisms in HIF-1α may exhibit different effects on cancer risk in Asians: evidence from nearly forty thousand participants

Y Liu, X Zhu, X Zhou, J Cheng, X Fu, J Xu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The effect of different SNPs in HIF-1α and cancer susceptibility remain indistinct. Here, we
evaluated the association between all identified SNPs (rs11549465, rs11549467 and …

Interaction Between Hypoxia-Inducible Factor 1-alpha Gene Polymorphism and Helicobacter pylori Infection on Gastric Cancer in a Chinese Tibetan Population

SH Li, Y Li, MJ Zhang, Q An, JN Tao, XH Wang - Biochemical Genetics, 2024 - Springer
To investigate the impact of four single nucleotide polymorphisms (SNPs) of the HIF1α gene
and its interaction with Helicobacter pylori (H. pylori) infection on susceptibility to gastric …

HIF-опосредованные механизмы взаимосвязи устойчивости к гипоксии и опухолевого роста

ДШ Джалилова, ОВ Макарова - Биохимия, 2021 - elibrary.ru
Кислородная недостаточность является одним из ключевых патогенетических
факторов, определяющих развитие и тяжесть течения многих заболеваний, в том …

Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital

T Tsukatani, T Minematsu, M Dai… - Wound Repair and …, 2021 - Wiley Online Library
Advances in patient care for pressure injuries (PIs) have reduced the prevalence of PIs in
Japan, although not in recent years. Several single‐nucleotide polymorphisms (SNPs) have …

[HTML][HTML] The role of angiogenetic single-nucleotide polymorphisms in thymic malignancies and thymic benign lesions

R Berardi, G Goteri, S Pagliaretta… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
Background We previously showed that selected single-nucleotide-polymorphisms (SNPs)
of genes involved in angiogenesis influence the aggressiveness of thymic epithelial tumors …

Molecular Evaluation of HIF-1α gene variation and determination of its frequency and association with breast cancer susceptibility in Saudi Arabia

R Mir, FM Abu-Duhier… - Endocrine, Metabolic & …, 2021 - ingentaconnect.com
Aim: Hypoxia-inducible factor 1 (HIF-1α) is responsible in regulating oxygen homeostasis in
tissues and is a central effector of the hypoxic response besides its protein overexpression …