Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

CYP2D6 is one of the most studied enzymes in the field of pharmacogenetics. The CYP2D6
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …

To date, the crystal structures of at least 12 human CYPs (1A2, 2A6, 2A13, 2C8, 2C9, 2D6,
2E1, 2R1, 3A4, 7A1, 8A1, and 46A1) have been determined. CYP2D6 accounts for only a …

Δ9-Tetrahydrocannabinol, cannabidiol (CBD), and cannabinol are the three major
cannabinoids contained in marijuana, which are devoid of nitrogen atoms in their structures …

Apatinib is a new oral antiangiogenic molecule that inhibits vascular endothelial growth
factor receptor-2. The present study aimed to determine the metabolism, pharmacokinetics …

CYP2B6 is mainly expressed in the liver that has been thought historically to play an
insignificant role in human drug metabolism. However, increased interest in this enzyme has …

CYP2D6, one of the major cytochrome P450 isoforms present in the human brain, is
associated with the incidence and prevalence of central nervous system (CNS) diseases …

Cytochrome P450 enzymes play key roles in the metabolism of the majority of drugs.
Improved models for prediction of likely metabolites will contribute to drug development. In …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

RS-Predictor is a tool for creating pathway-independent, isozyme-specific, site of
metabolism (SOM) prediction models using any set of known cytochrome P450 (CYP) …