Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern
recognition receptor ligation and activation of inflammatory pathways. Here, we studied how …

Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid
metabolism and many of these lipid genes are highly expressed in glial cells. However, the …

This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-
synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson's disease (PD) mice …

Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through
the lysosome. Although autophagy is highly conserved across all cell types, its activity in …