Microglia are the primary resident immune cells of the central nervous system.
Neuropathological reports have identified augmented microglial activation in brains of …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Synucleinopathies are a group of progressive neurodegenerative diseases known for the
accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn) …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million
individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and …

Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder
characterized by the aggregation of α-Synuclein (αSYN) building up intraneuronal …

Chronic sterile inflammation and persistent immune activation is a prominent pathological
feature of Parkinson's disease (PD). Inflammasomes are multi-protein intracellular signaling …

The intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared
pathological characteristics among neurodegenerative disorders collectively known as α …

Several genetic risk factors for Alzheimer's Disease (AD) implicate genes involved in lipid
metabolism and many of these lipid genes are highly expressed in glial cells. However, the …

Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory,
homeostatic phagocytosis of diverse types of cellular debris. Highly expressed on the …