Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
[HTML][HTML] Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
B Mathew, DGT Parambi, GE Mathew… - Archiv der …, 2019 - Wiley Online Library
No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson's disorder
S Kumar, JM Oh, MA Abdelgawad, MAS Abourehab… - ACS …, 2023 - ACS Publications
Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
RKP Tripathi, SR Ayyannan - Medicinal research reviews, 2019 - Wiley Online Library
Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …
indispensable approach of molecular and mechanistic diversity for the discovery of …
Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors
JM Oh, SC Baek, JP Lee, AR Tondo, O Nicolotti… - Bioorganic …, 2019 - Elsevier
The present study documents the synthesis of oxygenated chalcone (O1–O26) derivatives
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …
[HTML][HTML] Novel class of chalcone oxime ethers as potent monoamine oxidase-B and acetylcholinesterase inhibitors
JM Oh, TM Rangarajan, R Chaudhary, RP Singh… - Molecules, 2020 - mdpi.com
Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory
activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty …
activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty …
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: Synthesis and biochemical investigations
R Sasidharan, BH Eom, JH Heo, JE Park… - Journal of enzyme …, 2021 - Taylor & Francis
Abstract Nine compounds (MO1–MO9) containing the morpholine moiety were assessed for
their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase …
their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase …