Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries

D Iacopetta, J Ceramella, A Catalano, A D'Amato… - Antibiotics, 2023 - mdpi.com
Dental caries is a biofilm-mediated disease that represents a worldwide oral health issue.
Streptococcus mutans has been ascertained as the main cariogenic pathogen responsible …

Interference on iodine uptake and human thyroid function by perchlorate-contaminated water and food

G Lisco, A De Tullio, VA Giagulli, G De Pergola… - Nutrients, 2020 - mdpi.com
Background: Perchlorate-induced natrium-iodide symporter (NIS) interference is a well-
recognized thyroid disrupting mechanism. It is unclear, however, whether a chronic low …

Moderate exercise relieves fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway

Y Yu, R Niu, F Zhao, Y Zhao, J Wang, J Wang… - … Science and Pollution …, 2022 - Springer
With the intensification of environmental pollution, the content of fluoride is increasing in
human and animal living environments. Long-term fluoride exposure can cause damage to …

Uranium and fluoride accumulation in vegetable and cereal crops: a review on current status and crop-wise differences

S Sachdeva, MA Powell, G Nandini, H Kumar, R Kumar… - Sustainability, 2023 - mdpi.com
Uranium (U) and fluoride (F−) contamination in agricultural products, especially vegetable
and cereal crops, has raised serious concerns about food safety and human health on a …

Bioinformatics and genomic analyses of the suitability of eight riboswitches for antibacterial drug targets

N Pavlova, R Penchovsky - Antibiotics, 2022 - mdpi.com
Antibiotic resistance (AR) is an acute problem that results in prolonged and debilitating
illnesses. AR mortality worldwide is growing and causes a pressing need to research novel …

Distribution of fluoride in plasma, brain, and bones and associated oxidative damage after induced chronic fluorosis in Wistar rats

P Sharma, PK Verma, S Sood, R Singh, A Gupta… - Biological trace element …, 2022 - Springer
The study was aimed to determine fluoride levels in plasma, brain, and bones of Wistar rats
following chronic administration of fluoride at different dose levels and the consequent …

Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects

D Li, Q Zhao, L Xie, C Wang, Z Tian, H Tang… - Science of The Total …, 2023 - Elsevier
Evidence suggests that fluoride-induced neurodevelopment damage is linked to
mitochondrial disorder, yet the detailed mechanism remains unclear. A cohort of Sprague …

[HTML][HTML] Nrf2/PINK1-mediated mitophagy induction alleviates sodium fluoride-induced hepatic injury by improving mitochondrial function, oxidative stress, and …

C Song, A Zhang, M Zhang, Y Song, H Huangfu… - Ecotoxicology and …, 2023 - Elsevier
Mitophagy has distinct functions, which can lead to either protection or damage of tissues.
Though current evidence indicated that NaF triggers mitophagy, the role and regulation of …

Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis

X Li, J Yang, H Luo, Y Qiao, L Zhao… - Journal of Agricultural …, 2024 - ACS Publications
Male reproductive toxicity of fluoride is of great concern worldwide, yet the underlying
mechanism is unclear. Pyroptosis is a novel mode of inflammatory cell death, and riboflavin …

HIF-1α-mediated autophagy and canonical Wnt/β-catenin signalling activation are involved in fluoride-induced osteosclerosis in rats

S Zhu, J Liu, J Zhao, B Zhou, Y Zhang, H Wang - Environmental Pollution, 2022 - Elsevier
Fluoride (F) exposure can cause osteosclerosis, which is characterised by a high bone
mass, but its mechanism is not fully illustrated. Here, we aimed to evaluate the effects of …