[HTML][HTML] Glioblastoma: new therapeutic strategies to address cellular and genomic complexity

X Cai, ME Sughrue - Oncotarget, 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most invasive and devastating primary brain tumor with a median
overall survival rate about 18 months with aggressive multimodality therapy. Its unique …

[HTML][HTML] LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes

Z He, J Long, C Yang, B Gong, M Cheng… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Glioma is one of the most commonly diagnosed brain malignancies with a high cancer-
related death rate in humans. The prognosis of glioma patients is still unsatisfactory. In the …

[HTML][HTML] The role of microRNAs in multidrug resistance of glioblastoma

P Mahinfar, B Mansoori, D Rostamzadeh, B Baradaran… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is one of the most malignant types of central nervous
system tumor which accounts for more than 60% of all brain tumors in adults. Owing to poor …

HMGB3 promotes the proliferation and metastasis of glioblastoma and is negatively regulated by miR‐200b‐3p and miR‐200c‐3p

J Liu, L Wang, X Li - Cell Biochemistry and Function, 2018 - Wiley Online Library
High mobility group box 3 (HMGB3) is strongly involved in oncogenesis in a variety of
cancers. In the present study, we have explored the role of HMGB3 in glioblastoma …

[HTML][HTML] miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1

H Huang, J Tang, L Zhang, Y Bu… - … Journal of Oncology, 2018 - spandidos-publications.com
Chemotherapy is an important treatment option for gastric cancer (GC); however,
chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR) …

[HTML][HTML] Serum microRNA profiling in patients with glioblastoma: a survival analysis

H Zhao, J Shen, TR Hodges, R Song, GN Fuller… - Molecular cancer, 2017 - Springer
Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising
novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs …

MicroRNA-based drugs for brain tumors

S Anthiya, A Griveau, C Loussouarn, P Baril, M Garnett… - Trends in cancer, 2018 - cell.com
MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA
can downregulate the expression of multiple genes involved in diverse functions. Because …

[HTML][HTML] A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models

N Sadeghipour, SU Kumar, TF Massoud… - Scientific Reports, 2022 - nature.com
Glioblastoma (GBM) is the most common malignant brain tumor. Available treatments have
limited success because most patients develop chemoresistance. Alternative strategies are …

[HTML][HTML] Therapeutically significant microRNAs in primary and metastatic brain malignancies

AA Balachandran, LM Larcher, S Chen, RN Veedu - Cancers, 2020 - mdpi.com
Simple Summary The overall survival of brain cancer patients remains grim, with
conventional therapies such as chemotherapy and radiotherapy only providing marginal …

[HTML][HTML] The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells

S Brodie, HK Lee, W Jiang, S Cazacu, C Xiang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Despite advances in novel therapeutic approaches for the treatment of glioblastoma (GBM),
the median survival of 12-14 months has not changed significantly. Therefore, there is an …