The use of pigs in neuroscience: modeling brain disorders

NM Lind, A Moustgaard, J Jelsing, G Vajta… - Neuroscience & …, 2007 - Elsevier
The use of pigs in neuroscience research has increased in the past decade, which has seen
broader recognition of the potential of pigs as an animal for experimental modeling of …

Survival factors regulating ovarian apoptosis--dependence on follicle differentiation

E Markstrom, EC Svensson, R Shao… - …, 2002 - rep.bioscientifica.com
Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation

Y Yuan, LD Spate, BK Redel, Y Tian… - Proceedings of the …, 2017 - National Acad Sciences
Assisted reproductive technologies in all mammals are critically dependent on the quality of
the oocytes used to produce embryos. For reasons not fully clear, oocytes matured in vitro …

[HTML][HTML] Mitochondria directly influence fertilisation outcome in the pig

SH El Shourbagy, EC Spikings, M Freitas… - …, 2006 - rep.bioscientifica.com
The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major
generator of ATP. Our aim was to determine whether mitochondria alone could influence …

[HTML][HTML] Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

KE Park, AV Kaucher, A Powell, MS Waqas… - Scientific reports, 2017 - nature.com
Genome editing tools have revolutionized the generation of genetically modified animals
including livestock. In particular, the domestic pig is a proven model of human physiology …

In vitro production of embryos in swine

LR Abeydeera - Theriogenology, 2002 - Elsevier
In recent years, progress has been achieved in the production of pig embryos through IVM
and IVF techniques. Cytoplasmic maturation of oocytes has been improved by modifications …

The effects of resveratrol on porcine oocyte in vitro maturation and subsequent embryonic development after parthenogenetic activation and in vitro fertilization

SS Kwak, SA Cheong, Y Jeon, E Lee, KC Choi… - Theriogenology, 2012 - Elsevier
We investigated the effects of resveratrol, a phytoalexin with various pharmacologic
activities, on in vitro maturation (IVM) of porcine oocytes. We investigated intracellular …

Effect of follicular size on meiotic and developmental competence of porcine oocytes

R Marchal, C Vigneron, C Perreau, A Bali-Papp… - Theriogenology, 2002 - Elsevier
In several species, the developmental competence of the oocyte is acquired progressively
during late follicular growth, after the acquisition of the competence to resume and complete …

[HTML][HTML] PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during Fertilization*♦

ATH Wu, P Sutovsky, G Manandhar, W Xu… - Journal of Biological …, 2007 - ASBMB
We report a novel alkaline extractable protein of the sperm head that exclusively resides in
the post-acrosomal sheath region of the perinuclear theca (PT) and is expressed and …

Presence of β-mercaptoethanol can increase the glutathione content of pig oocytes matured in vitro and the rate of blastocyst development after in vitro fertilization

LR Abeydeera, WH Wang, TC Cantley, RS Prather… - Theriogenology, 1998 - Elsevier
The present study examined the effect of β-mercaptoethanol (BME) during in vitro maturation
(IVM) of pig oocytes on in vitro fertilization (IVF) parameters, intracellular glutathione (GSH) …