[HTML][HTML] Human trials exploring anti-aging medicines

L Guarente, DA Sinclair, G Kroemer - Cell Metabolism, 2024 - cell.com
Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

[HTML][HTML] Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Gut microbiome-targeted therapies for Alzheimer's disease

T Zhang, G Gao, LY Kwok, Z Sun - Gut microbes, 2023 - Taylor & Francis
The advent of highthroughput 'omics' technologies has improved our knowledge of gut
microbiome in human health and disease, including Alzheimer's disease (AD), a …

[HTML][HTML] Microbiota-gut-brain Axis Dysregulation in Alzheimer's disease: Multi-pathway effects and therapeutic potential

L Qu, Y Li, F Liu, Y Fang, J He, J Ma, T Xu… - Aging and …, 2024 - ncbi.nlm.nih.gov
An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the
gut microbiota. Alterations in intestinal permeability brought on by gut microbiota …

[HTML][HTML] Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with …

D Nimmons, N Aker, A Burnand, KP Jordan… - Neuroscience & …, 2023 - Elsevier
People living with dementia commonly experience anxiety, which is often challenging to
manage. We investigated the effectiveness of treatments for the management of anxiety in …

Quality management of probiotics: Ensuring safety and maximizing health benefits

JJ Ahire, A Rohilla, V Kumar, A Tiwari - Current microbiology, 2024 - Springer
Consumption of probiotics, which are beneficial live microorganisms, has received a lot of
attention because of their potential to improve health and wellness. Robust quality control …

[HTML][HTML] Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

M Fekete, A Lehoczki, D Major, V Fazekas-Pongor… - Nutrients, 2024 - mdpi.com
Recent research exploring the relationship between the gut and the brain suggests that the
condition of the gut microbiota can influence cognitive health. A well-balanced gut …

[HTML][HTML] The Anti-Inflammatory and Curative Exponent of Probiotics: A Comprehensive and Authentic Ingredient for the Sustained Functioning of Major Human Organs

MS Virk, MA Virk, Y He, T Tufail, M Gul, A Qayum… - Nutrients, 2024 - mdpi.com
Several billion microorganisms reside in the gastrointestinal lumen, including viruses,
bacteria, fungi, and yeast. Among them, probiotics were primarily used to cure digestive …

Evaluation of improvement of cognitive impairment in older adults with probiotic supplementation: A systematic review and meta-analysis

J Kou, H Kang, L Hu, D Wang, S Wang, Q Wang… - Geriatric Nursing, 2023 - Elsevier
Objective This study aimed to evaluate the improvement of cognitive impairment in older
adults through probiotic supplementation. Methods A literature review on probiotic …