Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Mounting evidence indicates that microglial activation contributes to neuronal damage in
neurodegenerative diseases. Recent studies show that in response to certain environmental …

Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …

Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Intracerebral hemorrhage (ICH) is one of the most lethal stroke subtypes. Despite the high
morbidity and mortality associated with ICH, its pathophysiology has not been investigated …

Abstract Rationale: Focused ultrasound (FUS), in conjunction with circulating microbubbles
(MBs), can be used to transiently increase the permeability of the blood-brain barrier (BBB) …

Recent works in the area of stroke and brain ischemia has demonstrated the significance of
the inflammatory response accompanying necrotic brain injury. Acutely, this response …

Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary
dysfunction, resulting in oedema formation and haemorrhagic conversion. There are …