Cholangiocarcinoma (CCA), the second most frequent liver cancer after hepatocellular
carcinoma, has been rising worldwide in recent epidemiological research. This neoplasia's …

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Overwhelming evidence points to an abnormally active Wnt/β-catenin signaling as a key
player in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA) is a pentacyclic …

Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

The Wnt signal transduction pathway has essential roles in the formation of the primary body
axis during development, cellular differentiation and tissue homeostasis. This animal …

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …

Bone resorption occurs after bone grafting, however, contemporaneous reconstruction of the
innervation of the bone graft is a potential treatment to maintain the bone mass of the graft …

The Wnt pathway has been recognized for its crucial role in human development and
homeostasis, but its dysregulation has also been linked to several disorders, including …

Abstract Ethnopharmacological relevance The mushroom Inonotus hispidus is traditional
Chinese medicine, which has been used to treat tumor illness for a long history in China …