miR‑29a‑3p inhibits the malignant characteristics of non‑small cell lung cancer cells by reducing the activity of the Wnt/β‑catenin signaling pathway

K Zhang, X Han, W Hu, C Su, B He - Oncology letters, 2022 - spandidos-publications.com
MicroRNAs (miRNAs) can influence non‑small cell lung cancer (NSCLC) in a tumor‑
suppressive and oncogenic manner. The present study aimed to investigate the effects and …

The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer

Y Xu, Y Sun, X Song, J Ren - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Cervical cancer (CC), the fourth most prevalent type of cancer among women worldwide, is
associated with high rates of morbidity and mortality. Due to the long period of latency in CC …

[HTML][HTML] From mesenchymal niches to engineered in vitro model systems: exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling

FI Ghuloum, CA Johnson, NA Riobo-Del Galdo… - Materials Today Bio, 2022 - Elsevier
Tissue patterning is the result of complex interactions between transcriptional programs and
various mechanical cues that modulate cell behaviour and drive morphogenesis. Vertebrate …

Factors affecting the role of canonical Wnt inhibitor Dickkopf-1 in cancer progression

D Doucet, C Brubaker, D Turner, CA Gregory - Frontiers in Oncology, 2023 - frontiersin.org
Background The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has the capacity to modulate
homeostasis between canonical and non-canonical Wnt pathways and also signal …

Negative effects of heat stress on ovarian tissue in female rabbit

L Tang, X Bai, X Xie, G Chen, X Jia, M Lei… - Frontiers in Veterinary …, 2022 - frontiersin.org
Numerous studies have highlighted the role of miRNA in the deformation and necrosis of
cells of ovarian tissue caused by heat stress (HS), which ultimately affects ovarian function …

[HTML][HTML] Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway, and induces senescence in hepatocellular carcinoma

X Yang, X Xiang, G Xu, S Zhou, T An… - Oncology Research, 2024 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), a common malignancy worldwide, still lacks effective
clinical treatment. The study aimed to investigate the oncogenes that affect the progression …

RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss

Y Peng, J Du, R Li, S Günther, N Wettschureck… - Cell Discovery, 2024 - nature.com
Multiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental
to guarantee long-term replenishment of the stem cell pool. Here, we describe that the G …

Research Progress on the Mechanism of the SFRP-Mediated Wnt Signalling Pathway Involved in Bone Metabolism in Osteoporosis

F An, J Song, W Chang, J Zhang, P Gao, Y Wang… - Molecular …, 2024 - Springer
Osteoporosis (OP) is a metabolic bone disease linked to an elevated fracture risk, primarily
stemming from disruptions in bone metabolism. Present clinical treatments for OP merely …

SPAG5, the upstream protein of Wnt and the target of curcumin, inhibits hepatocellular carcinoma

H Li, Y Qin, Y Huang, J Wang… - Oncology …, 2023 - spandidos-publications.com
The inhibitory role of curcumin on sperm-associated antigen 5 (SPAG5) and its effects on the
cancer‑related Wnt classical signaling pathway has been previously demonstrated …

Comparative transcriptome and proteome analysis explores the antitumor key regulators of ergosterone in H22 tumor-bearing mice

Z Li, H Bao - European Journal of Pharmacology, 2023 - Elsevier
Ergosterone has been proved to have potential antitumor effect on H22 tumor-bearing mice,
but the antitumor mechanism and key regulators are still unclear. The current study was …