Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

The ability to repair or promote regeneration within the adult human brain has been
envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors …

In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Huntington's disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss
of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell …

Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially
because the injury-induced neuronal loss cannot be easily replenished through …

Direct reprogramming based on genetic factors resembles a promising strategy to replace
lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a …

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

Stroke may cause severe death and disability but many clinical trials have failed in the past,
partially because the lack of an effective method to regenerate new neurons after stroke. In …