New insights into natural products that target the gut microbiota: Effects on the prevention and treatment of colorectal cancer

L Lu, J Dong, Y Liu, Y Qian, G Zhang, W Zhou… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancer (CRC) is one of the most common malignant carcinomas. CRC is
characterized by asymptomatic onset, and most patients are already in the middle and …

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Y Zou, S Wang, H Zhang, Y Gu, H Chen… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, colorectal cancer has reported a higher incidence in younger adults
and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation …

Manipulating microbiota in inflammatory bowel disease treatment: Clinical and natural product interventions explored

M Zhu, Y Song, Y Xu, H Xu - International journal of molecular sciences, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease,
that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively …

Wheat germ-derived peptide alleviates dextran sulfate sodium-induced colitis in mice

F Wang, Y Chen, K Itagaki, B Zhu, Y Lin… - Journal of Agricultural …, 2023 - ACS Publications
This study explores the protective properties and potential mechanisms of wheat-germ-
derived peptide APEPEPAF (APE) against ulcerative colitis. Colitis mice induced by dextran …

Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis

J Liu, L Sun, D Chen, X Huo, X Tian, J Li, M Liu, Z Yu… - Food & function, 2022 - pubs.rsc.org
Inhibition of ferroptosis in intestinal epithelial cells ameliorates clinical symptoms and
improves endoscopic presentations in inflammatory bowel disease (IBD). Licorice is used …

Natural products modulate NLRP3 in ulcerative colitis

JC Xue, S Yuan, XT Hou, H Meng, BH Liu… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC) is a clinically common, progressive, devastating, chronic inflammatory
disease of the intestine that is recurrent and difficult to treat. Nod-like receptor protein 3 …

Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice via Remodeling Gut Microbiota

Z Dai, S Li, Y Meng, Q Zhao, Y Zhang, Z Suonan, Y Sun… - Nutrients, 2022 - mdpi.com
Capsaicin is a pungent alkaloid abundantly present in peppers with outstanding biological
activities, including the anti-atherosclerosis effect. Previous studies revealed that gut …

Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota–Gut–Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia

P Liu, X Zhou, H Zhang, R Wang, X Wu, W Jian… - Frontiers in …, 2022 - frontiersin.org
Danggui-Shaoyao-San (DSS) has a long history of being used as a traditional medicine
(TCM) and has been reported to show therapeutic effects in alleviating the symptoms of …

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Z Wang, G Xu, Z Li, X Xiao, J Tang… - Journal of Inflammation …, 2022 - Taylor & Francis
Inflammation is the tissues' defense response after the body is stimulated by microbial
infection or damage signals, and it is initiated when pattern recognition receptors recognize …

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

L Zeng, K Yang, G Yu, W Hao, X Zhu, A Ge… - Cell Death & …, 2024 - nature.com
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …