Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …

Hypertension is one of the most common medical com-plications of pregnancy that affects
both fetal and maternal health and is often life threatening. 1, 2 Multiple maternal organs are …

Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for
the neuroinflammatory disease neuromyelitis optica (NMO). We measured the binding of …

Since the discovery of aquaporins, it has become clear that the various mammalian
aquaporins play critical physiological roles in water and ion balance in multiple tissues …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

The role of changes in the extracellular potassium concentration [K+] o in epilepsy has
remained unclear. Historically, it was hypothesized that [K+] o is the causal factor for …

Astrocytes play a key role for maintenance of brain water homeostasis, but little is known
about mechanisms of short‐term regulation of astrocyte water permeability. Here, we report …

Neuronal signaling in the central nervous system (CNS) associates with release of K+ into
the extracellular space resulting in transient increases in [K+] o. This elevated K+ is swiftly …