Alzheimer's disease
JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …
functional decline associated with age together with a particular neuropathology. It was first …
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease
Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
Global estimates on the number of persons across the Alzheimer's disease continuum
A Gustavsson, N Norton, T Fast, L Frölich… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
GJ Biessels, F Despa - Nature Reviews Endocrinology, 2018 - nature.com
Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
2018 Alzheimer's disease facts and figures
Alzheimer's Association - Alzheimer's & Dementia, 2018 - Elsevier
This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …
A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications
JA Frontera, D Yang, A Lewis, P Patel… - Journal of the …, 2021 - Elsevier
Background Little is known regarding long-term outcomes of patients hospitalized with
COVID-19. Methods We conducted a prospective study of 6-month outcomes of hospitalized …
COVID-19. Methods We conducted a prospective study of 6-month outcomes of hospitalized …
Association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment …
GD Rabinovici, C Gatsonis, C Apgar, K Chaudhary… - Jama, 2019 - jamanetwork.com
Importance Amyloid positron emission tomography (PET) detects amyloid plaques in the
brain, a core neuropathological feature of Alzheimer disease. Objective To determine if …
brain, a core neuropathological feature of Alzheimer disease. Objective To determine if …
Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized …
Combining physical exercise with cognitive training is a popular intervention in dementia
prevention trials and guidelines. However, it remains unclear what combination strategies …
prevention trials and guidelines. However, it remains unclear what combination strategies …
[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …