Background Previous randomised controlled trials comparing bladder preservation with
radical cystectomy for muscle-invasive bladder cancer closed due to insufficient accrual …

Urothelial carcinoma (UC) is a common cancer associated with a poor prognosis in patients
with advanced disease. Platinum-based chemotherapy has remained the cornerstone of …

Radical cystectomy with perioperative chemotherapy remains the gold standard treatment
for MIBC patients. Nevertheless, BSS can be considered a viable option in selected patients …

Objective We report NHS England data for patients with bladder cancer (BC), upper tract
urothelial cancer (UTUC: renal pelvic and ureteric), and urethral cancers from 2013 to 2019 …

Simple Summary Online adaptive radiotherapy (ART) allows adaptation of the dose
distribution to the anatomy captured with pre-adaptation imaging. Since ART is time …

Multimodal bladder preservation therapy is already an alternative for patients with muscle-
invasive bladder cancer (MIBC) who are unable or unwilling to undergo radical cystectomy …

Cancer-associated fibroblasts (CAFs) play a fundamental role in the development of cancers
and their response to therapy. In recent years, CAFs have returned to the spotlight as …

Objective To update the CCAFU recommendations for the management of muscle invasive
bladder carcinoma (MIBC). Methods A systematic review (Medline) of the literature from …

Over the last two to three decades the non-surgical curative management of bladder cancer
has significantly progressed. Increasing evidence supports the use of bladder preservation …

Background Radiation may improve the efficacy of immune checkpoint inhibition. This study
investigates the combination of pembrolizumab and chemoradiation (CRT) for muscle …