Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases

J Liu, Y Gu, M Guo, X Ji - CNS neuroscience & therapeutics, 2021 - Wiley Online Library
As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Turning the oxygen dial: balancing the highs and lows

AH Baik, IH Jain - Trends in cell biology, 2020 - cell.com
Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the
human body and is required for several hundred diverse biochemical reactions. The …

The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia

B Pomierny, W Krzyżanowska, J Jurczyk… - International journal of …, 2021 - mdpi.com
Ischemic stroke is the third leading cause of death in the world, which accounts for almost
12% of the total deaths worldwide. Despite decades of research, the available and effective …

Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update

C Torres-Querol, M Quintana-Luque, G Arque… - Scientific reports, 2021 - nature.com
Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke
patients. It has been proven that RIC reduces infarct size and improves functional outcomes …

Remote but not distant: a review on experimental models and clinical trials in remote ischemic conditioning as potential therapy in ischemic stroke

I Mollet, JP Marto, M Mendonça, MV Baptista… - Molecular …, 2022 - Springer
Stroke is one of the main causes of neurological disability worldwide and the second cause
of death in people over 65 years old, resulting in great economic and social burden …

The role and mechanisms of microvascular damage in the ischemic myocardium

BH Zhao, A Ruze, L Zhao, QL Li, J Tang… - Cellular and Molecular …, 2023 - Springer
Following myocardial ischemic injury, the most effective clinical intervention is timely
restoration of blood perfusion to ischemic but viable myocardium to reduce irreversible …

Effects of ischemic postconditioning and long non-coding RNAs in ischemic stroke

W Ma, K Zhu, L Yin, J Yang, J Zhang, H Wu, K Liu… - …, 2022 - Taylor & Francis
Stroke is a main cause of disability and death among adults in China, and acute ischemic
stroke accounts for 80% of cases. The key to ischemic stroke treatment is to recanalize the …

Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress

F Li, X Geng, H Lee, M Wills, Y Ding - Frontiers in Cellular …, 2021 - frontiersin.org
While it is well-known that pre-stroke exercise conditioning reduces the incidence of stroke
and the development of comorbidities, it is unclear whether post-stroke exercise …

Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review

RC Sharp, DT Guenther, MJ Farrer - Frontiers in Immunology, 2023 - frontiersin.org
Objective The aim of this study was to systematically review the neuroimmunology literature
to determine the average immune cell counts reported by flow cytometry in wild-type (WT) …

Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat …

W Wang, L Xie, X Zou, N Li, Y Yang, Z Wu… - International …, 2021 - Elsevier
Background Cerebral ischemia–reperfusion injury (CIRI) is the leading cause of poor
neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported …