The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives
C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …
Candida albicans-Biology, molecular characterization, pathogenicity, and advances in diagnosis and control–An update
Candida albicans is an emerging multidrug-resistant fungal pathogen representing an
important source of invasive disease in humans and generating high healthcare costs …
important source of invasive disease in humans and generating high healthcare costs …
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Clearance of invading microbes requires phagocytes of the innate immune system.
However, successful pathogens have evolved sophisticated strategies to evade immune …
However, successful pathogens have evolved sophisticated strategies to evade immune …
[HTML][HTML] Candidalysin: discovery and function in Candida albicans infections
Highlights•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …
Mechanism of Candida pathogenesis: revisiting the vital drivers
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
X Ding, H Kambara, R Guo, A Kanneganti… - Nature …, 2021 - nature.com
Candida albicans is the most common cause of fungal sepsis. Inhibition of inflammasome
activity confers resistance to polymicrobial and LPS-induced sepsis; however …
activity confers resistance to polymicrobial and LPS-induced sepsis; however …
Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans
S Mogavero, FM Sauer, S Brunke, S Allert… - Cellular …, 2021 - Wiley Online Library
The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections.
Although the ability to transition from the yeast to the hypha morphology is essential for …
Although the ability to transition from the yeast to the hypha morphology is essential for …
Candida albicans-induced epithelial damage mediates translocation through intestinal barriers
S Allert, TM Förster, CM Svensson, JP Richardson… - MBio, 2018 - Am Soc Microbiol
Life-threatening systemic infections often occur due to the translocation of pathogens across
the gut barrier and into the bloodstream. While the microbial and host mechanisms …
the gut barrier and into the bloodstream. While the microbial and host mechanisms …
Candida albicans–epithelial interactions and induction of mucosal innate immunity
Highlights•Candidalysin is the first peptide toxin identified in any human fungal
pathogen.•Epithelial cells identify invasive C. albicans by detecting Candidalysin …
pathogen.•Epithelial cells identify invasive C. albicans by detecting Candidalysin …
The pathobiology of human fungal infections
Human fungal infections are a historically neglected area of disease research, yet they
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …
cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of …