Introduction: Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that
plays a key causative role in several neurodegenerative diseases, especially in the …

The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …

Mitochondrial dysfunction in the spinal cord is a hallmark of amyotrophic lateral sclerosis
(ALS), but the neurometabolic alterations during early stages of the disease remain …

Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting
the motor neurons, resulting in the death of patients. The disease is either sporadic or …

Progressive degeneration of motor neurons (MNs) is the hallmark of amyotrophic lateral
sclerosis (ALS). Limb-innervating lateral motor column MNs (LMC-MNs) seem to be …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease
affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation …

Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …

Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron
disease. The disease is characterized by protein aggregates. The symptoms include …

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of
motor neurons in adults, with a median survival of 3–5 years after appearance of symptoms …