The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …

Although drugs of abuse have different chemical structures and interact with different protein
targets, all appear to usurp common neuronal systems that regulate reward and motivation …

The addictive properties of psychostimulants such as cocaine, amphetamine,
methamphetamine, and methylphenidate are based on their ability to increase …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Cocaine (benzoylmethylecgonine), a natural alkaloid, is a powerful psychostimulant and a
highly addictive drug. Unfortunately, the relationships between its behavioral and …

Drugs of abuse have been reported to produce both rewarding and aversive effects, as
evidenced by their ability to induce both conditioned place preferences (CPPs) and …

Individual differences are a hallmark of drug addiction. Here, we describe a rat model based
on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine …

Individual and developmental differences in novelty seeking have been implicated in
differential sensitivity to psychostimulants in rodents, but findings are mixed. The extent to …

Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans.
Acute locomotor activation in response to psychostimulants is commonly used as an animal …