A guide to cell death pathways

J Yuan, D Ofengeim - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

The cell biology of ferroptosis

SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

7-Dehydrocholesterol dictates ferroptosis sensitivity

Y Li, Q Ran, Q Duan, J Jin, Y Wang, L Yu, C Wang… - Nature, 2024 - nature.com
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …

A guideline on the molecular ecosystem regulating ferroptosis

E Dai, X Chen, A Linkermann, X Jiang, R Kang… - Nature cell …, 2024 - nature.com
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Y Li, Z Cai, W Ma, L Bai, E Luo, Y Lin - Bone Research, 2024 - nature.com
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the
bone health of patients with diabetes; however, currently, there are no effective treatment …

The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death

Y Ai, Y Meng, B Yan, Q Zhou, X Wang - Molecular Cell, 2024 - cell.com
Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual Review of …, 2023 - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …