HIV-1 maturation: lessons learned from inhibitors
AB Kleinpeter, EO Freed - Viruses, 2020 - mdpi.com
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …
effective therapies has accompanied a massive increase in our understanding of the …
The role of integration and clonal expansion in HIV infection: live long and prosper
EM Anderson, F Maldarelli - Retrovirology, 2018 - Springer
Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …
Cellular and molecular mechanisms of HIV-1 integration targeting
AN Engelman, PK Singh - Cellular and Molecular Life Sciences, 2018 - Springer
Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …
Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition
AN Engelman - Journal of Biological Chemistry, 2019 - ASBMB
Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …
Multiple, switchable protein: RNA interactions regulate human immunodeficiency virus type 1 assembly
P Bieniasz, A Telesnitsky - Annual review of virology, 2018 - annualreviews.org
Human immunodeficiency virus type 1 (HIV-1) particle assembly requires several protein:
RNA interactions that vary widely in their character, from specific recognition of highly …
RNA interactions that vary widely in their character, from specific recognition of highly …
Multimodal functionalities of HIV-1 integrase
AN Engelman, M Kvaratskhelia - Viruses, 2022 - mdpi.com
Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
JL Elliott, JE Eschbach, PC Koneru, W Li… - Elife, 2020 - elifesciences.org
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
PC Koneru, AC Francis, N Deng, SV Rebensburg… - Elife, 2019 - elifesciences.org
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral
agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we …
agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we …
Going beyond integration: The emerging role of HIV-1 integrase in virion morphogenesis
JL Elliott, SB Kutluay - Viruses, 2020 - mdpi.com
The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …
Biological and structural analyses of new potent allosteric inhibitors of HIV-1 integrase
D Bonnard, E Le Rouzic, MR Singer, Z Yu… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
ABSTRACT HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs) share the binding site on
the viral protein with the host factor LEDGF/p75. These small molecules act as molecular …
the viral protein with the host factor LEDGF/p75. These small molecules act as molecular …