Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …

Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …

Human immunodeficiency virus type 1 (HIV-1) particle assembly requires several protein:
RNA interactions that vary widely in their character, from specific recognition of highly …

Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral
agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we …

The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …

ABSTRACT HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs) share the binding site on
the viral protein with the host factor LEDGF/p75. These small molecules act as molecular …