[HTML][HTML] Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022 - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Artificial scaffolds in cardiac tissue engineering

JA Roacho-Pérez, EN Garza-Treviño… - Life, 2022 - mdpi.com
Cardiovascular diseases are a leading cause of death worldwide. Current treatments
directed at heart repair have several disadvantages, such as a lack of donors for heart …

Cysteine-based redox-responsive nanoparticles for fibroblast-targeted drug delivery in the treatment of myocardial infarction

X Ji, Y Meng, Q Wang, T Tong, Z Liu, J Lin, B Li, Y Wei… - ACS …, 2023 - ACS Publications
Upon myocardial infarction (MI), activated cardiac fibroblasts (CFs) begin to remodel the
myocardium, leading to cardiac fibrosis and even heart failure. No therapeutic approaches …

The ethical implications of tissue engineering for regenerative purposes: A systematic review

AFJ de Kanter, KR Jongsma, MC Verhaar… - … Engineering Part B …, 2023 - liebertpub.com
Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem
cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs …

Pre-conditioning methods and novel approaches with mesenchymal stem cells therapy in cardiovascular disease

A Matta, V Nader, M Lebrin, F Gross, AC Prats… - Cells, 2022 - mdpi.com
Transplantation of mesenchymal stem cells (MSCs) in the setting of cardiovascular disease,
such as heart failure, cardiomyopathy and ischemic heart disease, has been associated with …

[HTML][HTML] Exosomes as a cell-free therapy for myocardial injury following acute myocardial infarction or ischemic reperfusion

Z An, J Tian, Y Liu, X Zhao, X Yang, J Yong… - Aging and …, 2022 - ncbi.nlm.nih.gov
Exosomes, which contain miRNA, have been receiving growing attention in cardiovascular
therapy because of their role in mediating cell-cell communication, autophagy, apoptosis …

Advances in cardiac tissue engineering

T Kitsuka, F Takahashi, J Reinhardt, T Watanabe… - Bioengineering, 2022 - mdpi.com
Tissue engineering has paved the way for the development of artificial human cardiac
muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial …

Regulation of endothelial progenitor cell functions in ischemic heart disease: new therapeutic targets for cardiac remodeling and repair

H Huang, W Huang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide.
Ischemia and hypoxia following myocardial infarction (MI) cause subsequent cardiomyocyte …

Precise metabolomics defines systemic metabolic dysregulation distinct to acute myocardial infarction associated with diabetes

J Xia, B Li, H Zhang, Q Li, SM Lam, C Yin… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: Acute myocardial infarction (AMI) is a leading cause of death and disability.
Diabetes is an important risk factor and a common comorbidity in AMI patients. The higher …