The membrane of cells and intracellular organelles is 2 composed of two layers of lipids,
preventing the free “in 3 and out” movement of water and solutes that are necessary 4 for …

Diseases that induce a loss of renal function affect a substantial portion of the world's
population and can range from a slight decline in the glomerular filtration rate or …

There is clinical evidence that increased urinary serine proteases are associated with the
disease severity in the setting of diabetic nephropathy (DN). Elevation of serine proteases …

Abstract The mammalian Transient Receptor Potential Canonical (TRPC) subfamily
comprises seven transmembrane proteins (TRPC1–7) forming cation channels in the …

Several reports previously investigated the Transient Receptor Potential Canonical
subfamily channel 3 (TRPC3) in the kidney. However, most of the conclusions are based on …

This review outlines the features of tandem regulation of glomerular microcirculation by
autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points …

Hyperglycemia and increased activity of the renal angiotensin II (ANG II) system are two
primary pathogenic stimuli for the onset and progression of podocyte injury in diabetic …

Angiotensin receptor blockers (ARBs) are the first-line treatment for hypertension; they act by
inhibiting signaling through the angiotensin 1 receptor (AT1R). Recently, a novel biased …

The transient receptor potential (TRP) channel superfamily is a group of non-selective cation
channels functioning as cellular sensors for a wide range of physical, chemical and …

Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder
impairing renal cell function. Mitochondria, crucial organelles, play a key role in substance …