Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb
Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains …

The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

The dysregulation of NLRP 3 inflammasome can cause uncontrolled inflammation and drive
the development of a wide variety of human diseases, but the medications targeting NLRP 3 …

Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …