Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

Hypertension is a primary risk factor for cardiovascular diseases including myocardial
infarction and stroke. Major determinants of blood pressure are vasodilatory factors such as …

Nitric oxide (NO) is a gaseous lipophilic free radical generated by three distinct isoforms of
nitric oxide synthases (NOS), type 1 or neuronal (nNOS), type 2 or inducible (iNOS) and type …

Shear stress imposed by blood flow is crucial for maintaining vascular homeostasis. We
examined the role of shear stress in regulating SIRT1, an NAD+-dependent deacetylase …

Nitric oxide (NO) has been implicated in several cellular processes as a signaling molecule
and also as a source of reactive nitrogen species (RNS). NO is produced by three …

The endothelium lining the inner surface of blood vessels of the cardiovascular system is
constantly exposed to hemodynamic shear stress. The interaction between endothelial cells …

Nitric oxide (NO) is a lipophilic, highly diffusible and short-lived physiological messenger
which regulates a variety of important physiological responses including vasodilation …

The mechanisms of testosterone-induced vasodilatation are not fully understood. This study
investigated the effect of testosterone on nitric oxide (NO) synthesis and its molecular …

Human endothelial nitric oxide synthase (NOS3) gene polymorphism at Exon 7 (Glu298Asp)
has been linked to vascular endothelial dysfunction, but the mechanisms are not defined …