[HTML][HTML] Genetic and environmental influences interact with age and sex in shaping the human methylome
The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …
sex and age, resulting in sex-and age-related physiological variation and disease …
In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures
LL Schmitz, V Duque - … of the National Academy of Sciences, 2022 - National Acad Sciences
Research on maternal-fetal epigenetic programming argues that adverse exposures to the
intrauterine environment can have long-term effects on adult morbidity and mortality …
intrauterine environment can have long-term effects on adult morbidity and mortality …
[HTML][HTML] Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
S Horvath, C Pirazzini, MG Bacalini, D Gentilini… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …
the genetic and molecular determinants of healthy ageing and longevity. Semi …
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …
function and chronic disease and have led to the development of geroscience-guided …
Association of pace of aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia
Background and Objectives DNA methylation algorithms are increasingly used to estimate
biological aging; however, how these proposed measures of whole-organism biological …
biological aging; however, how these proposed measures of whole-organism biological …
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …
Weismann. However, being metabolically active, the germ line accumulates damage and …
DNA methylation-based age clocks: From age prediction to age reversion
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …
progressive decline in physiological functionality and enhanced disease vulnerability …
Epigenetic age acceleration reflects long-term cardiovascular health
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …
disease risks independent of chronological age. It may serve as a useful biomarker of …
Early-life adversity and neurological disease: age-old questions and novel answers
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …
over 50 million people worldwide, imposing a substantial burden on individuals and society …
Calorie restriction and aging in humans
Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …