Aging-Oxidative stress, antioxidants and computational modeling
F Hussain, HUR Kayani - Heliyon, 2020 - cell.com
Aging is a degenerative, biological, time-dependent, universally conserved process thus
designed as one of the highest known risk factors for morbidity and mortality. Every …
designed as one of the highest known risk factors for morbidity and mortality. Every …
Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders
Background: Neurodegenerative disorders (NDs) are diverse group of disorders
characterized by escalating loss of neurons (structural and functional). The development of …
characterized by escalating loss of neurons (structural and functional). The development of …
Docking with swissdock
G Bitencourt-Ferreira, WF de Azevedo - Docking screens for drug …, 2019 - Springer
Protein-ligand docking simulation is central in drug design and development. Therefore, the
development of web servers intended to docking simulations is of pivotal importance …
development of web servers intended to docking simulations is of pivotal importance …
Computational studies applied to flavonoids against Alzheimer's and Parkinson's diseases
AFM Monteiro, JDO Viana, A Nayarisseri… - Oxidative medicine …, 2018 - Wiley Online Library
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …
[HTML][HTML] Investigation of the acute toxicity of new xanthine xenobiotics with noticeable antioxidant activity
D Vasylyev, B Priimenko, K Aleksandrova… - Ukrainian Journal of …, 2021 - cyberleninka.ru
Over the last few decades, there was significant interest in applying various xanthine
derivatives to treat several diseases as highly potent antioxidant agents. Our study …
derivatives to treat several diseases as highly potent antioxidant agents. Our study …
Anti‐acetylcholinesterase, antidiabetic, anti‐inflammatory, antityrosinase and antixanthine oxidase activities of Moroccan propolis
S El‐Guendouz, S Aazza, B Lyoussi… - … Journal of Food …, 2016 - Wiley Online Library
Biological properties of Moroccan propolis have been scarcely studied. In the present work,
the total phenols and flavonoids from 21 samples of propolis collected in different places of …
the total phenols and flavonoids from 21 samples of propolis collected in different places of …
Pteryxin-a promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea
Pteryxin is a dihydropyranocoumarin derivative found in Apiaceae family. In this study,
pteryxin, which was previously isolated from the fruits of Mutellina purpurea, was …
pteryxin, which was previously isolated from the fruits of Mutellina purpurea, was …
Multi-combined 3D-QSAR, docking molecular and ADMET prediction of 5-azaindazole derivatives as LRRK2 tyrosine kinase inhibitors
The enzyme Leucine-rich repeat kinase 2 (LRRK2) has become a target of therapeutic
interest in Parkinson research. Athree-dimensional quantitative structure-activity …
interest in Parkinson research. Athree-dimensional quantitative structure-activity …
3D-QSAR and in-silico studies of natural products and related derivatives as monoamine oxidase inhibitors
Background: The computational development of human monoamine oxidase (MAO)
inhibitors led to advancement in drug design and the treatment of many neurodegenerative …
inhibitors led to advancement in drug design and the treatment of many neurodegenerative …
Advantages of structure-based drug design approaches in neurological disorders
Objective: The purpose of the review is to portray the theoretical concept on neurological
disorders from research data. Background: The freak changes in chemical response of …
disorders from research data. Background: The freak changes in chemical response of …