Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Pain and depression are frequently co-existent in clinical practice, yet the underlying
mechanisms remain largely to be determined. Microglia activation and subsequent pro …

Background Discoveries that microglia-mediated neuroinflammation is involved in the
pathological process of depression provided a new strategy for novel antidepressant …

Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of
the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still …

Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous
system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a …

Progression of major depression, a multifactorial disorder with a neuroinflammatory
signature, seems to be associated with the disruption of body allostasis. High rates of …

Although accumulating evidence suggests that activated microglia are associated with
deficits in neurogenesis and contribute to the physiopathology of major depressive disorder …

Depression and anxiety commonly occur in chronic pain states and the coexistence of these
diseases worsens outcomes for both disorders and may reduce treatment adherence and …

Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet,
current treatments targeting serotonergic and noradrenaline reuptake systems are …

Recent studies suggest that CCR5 and its ligands are important regulators for the
development of neuropathic pain and that their modulation can have some beneficial …