Depression and chronic pain have been estimated to co-occur in up to 80% of patients
suffering from these disorders, with this co-morbidity being more disabling and more …

Background The endocannabinoid (eCB) system, an endogenous lipid signaling system,
appears to be dysregulated in depression. The role of endocannabinoids (eCBs) as potent …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

Patients with neuropathic pain induced by nerve injury usually present with co-morbid
affective changes, such as depression. Neuroglia was reported to play an important role in …

Elevated microglial/macrophage-associated biomarkers in the cerebrospinal fluid of infant
victims of abusive head trauma (AHT) suggest that these cells play a role in the …

BACKGROUND: Pain and depression are highly prevalent symptoms in cancer patients.
They tend to occur simultaneously and affect each other and share biological pathways and …

A relationship between neuroinflammation and the development of psychiatric disorder have
been revealed by many studies in the past decade. Although studies have shown that …

Microglia can modulate spinal nociceptive transmission. Yet, their role in spinal cord
stimulation (SCS)-induced pain inhibition is unclear. Here, we examined how SCS affects …

Clinical evidence indicates that major depression is a common comorbidity of chronic pain,
including neuropathic pain. However, the cellular basis for chronic pain-mediated major …

Objectives The objectives of the study were to determine if adjunctive minocycline mitigates
depressive symptom severity and improves cognitive function in individuals with bipolar I/II …