Cervical cancer is one of the main causes of cancer death in women globally, and its
epidemiology is similar to that of a low-infectious venereal illness. Many sexual partners and …

Chronic myeloid leukemia (cml) results from expression of the constitutive tyrosine kinase
activity of the Bcr-Abl oncoprotein. Imatinib, a tyrosine kinase inhibitor (tki), is highly effective …

Objective: Consistent use of imatinib is critical for treatment success in chronic myeloid
leukemia, yet perfect adherence to the prescribed clinical regimen is reported to be as low …

Introduction: Real-world data on usage of 1st-, 2nd-, and 3rd-generation tyrosine kinase
inhibitor (TKI) in chronic myeloid leukemia (CML) are scarce. This study therefore aimed to …

Cutaneous manifestations of myeloid malignancies are common and have a broad range of
presentations. These skin findings are classified as specific, due to direct infiltration by …

Background Currently the majority of cancer patients are considered ineligible for intensive
care treatment and oncologists are struggling to get their patients admitted to intensive care …

Protein kinases have emerged as attractive targets for treatment of several diseases
prompting large-scale phosphoproteomics studies to elucidate their cellular actions and the …

Background: T-cell acute lymphoblastic leukemia is a hematologic malignancy
characterized by T-cell proliferation, and in many cases, the ectopic expression of the …

A leucemia mieloide crônica (LMC) é uma neoplasia da medula óssea originada da
translocação entre os cromossomos 9 e 22 t (9: 22)(q34; 11) e forma o gene híbrido BCR …

Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has
been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small …