Inleiding: De opkomst van de orale doelgerichte antitumorale therapie brengt een aantal
voor-en nadelen met zich mee. De patiënt krijgt zijn medicatie niet langer intraveneus …

Historically, bleeding due to hemophilia is characterized primarily by joint bleeding leading
to joint arthritis and pain. Infectious diseases also have posed significant morbidity and …

Purpose: Chronic myeloid leukemia (CML) treatment has improved significantly in the last
decade with the introduction of tyrosine kinase inhibitors (TKIs), which target BCR/ABL …

Nous étudions une nouvelles familles d'inhibiteurs de kinase: les benzopyridoindole. Ces
molécules ont des effets antiprolifératifs sur des lignées cancéreuses et représentent les …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of pluripotent
hematopoietic stem cells characterized by the presence of the Philadelphia chromosome …

The better understanding of the CML biology provided by the latest researches requires a
deeper knowledge about the epidemiologic data in each geographic area, so the compiling …

Tyrosine kinase inhibitors (TKIs) are promising agents for specific inhibition of malignant cell
growth and metastasis formation. They directly interfere with TK enzymes that are activated …

Chronic myelogenous leukemia (CML) is a disorder in which an excessive number of blood
stem cells develop into the white blood cell group called granulocytes. The anticancer drug …

Since the introduction of imatinib mesylate, the 'first generation'tyrosine kinase inhibitor
(TKI), into the clinic in 1998, the drug has become the preferred treatment for the majority, if …

Leukaemias comprise a heterogeneous group of clonal disorders of haemopoiesis, affecting
both haemopoietic stem cells and progenitor cells within the myeloid and lymphocytic …