Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that
could replenish functional homeostasis similarly to, eg, skin or the hematopoietic system …

Human induced pluripotent stem cell (hiPSC)-derived kidney organoids have prospective
applications ranging from basic disease modelling to personalised medicine. However …

Mammalian nephron endowment is determined by the coordinated cessation of
nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1+ …

Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the
contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I …

Congenital renal tract malformations (RTMs) are the major cause of severe kidney failure in
children. Studies to date have identified defined genetic causes for only a minority of human …

Summary R-spondin 2 (RSPO2) drives the potentiation of Wnt signaling and is implicated in
tumorigenesis in multiple cancers, but its role in ovarian cancer has not been investigated …

Nephron endowment, defined during the fetal period, dictates renal and related
cardiovascular health throughout life. We show here that, despite its negative effects on …

The kidney plays an integral role in filtering the blood—removing metabolic by-products from
the body and regulating blood pressure. This requires the establishment of large numbers of …

Paracrine cell-cell communication is central to all developmental processes, ranging from
cell diversification to patterning and morphogenesis. Precise calibration of signaling strength …