Mismatch repair (MMR) system maintains genome integrity by correcting mispaired or
unpaired bases which have escaped the proofreading activity of DNA polymerases. The …

Microsatellites—tandem repeats of short DNA motifs—are abundant in the human genome
and have high mutation rates. While microsatellite instability is implicated in numerous …

Background Microsatellites are frequently used genetic markers in a wide range of
applications, primarily due to their high length polymorphism levels that can easily be …

OBJECTIVE: The effects of DNA methyltransferase (DNMT) inhibitor RG108 on the
proliferation and apoptosis of endometrial cancer was investigated, and whether its …

Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously
studied mutations within a (CA) 13 microsatellite using an enhanced green fluorescent …

Microsatellite markers are extensively used to evaluate genetic diversity in natural or
experimental evolving populations. Their high degree of polymorphism reflects their high …

Here, we report the investigation of microsatellite instability (MSI) in human cells with a
newly developed reporter system based on fluorescence. We composed a vector into which …

Microsatellite instability promotes colonic tumorigenesis through generating frameshift
mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and …

It is generally accepted that longer microsatellites mutate more frequently in defective DNA
mismatch repair (MMR) than shorter microsatellites. Indeed, we have previously observed …

Microsatellites mutate frequently by replication slippage. Empirical evidence shows that the
probability of such slippage mutations may increase with the length of the repeat region as …