Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and
tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

The Notch genes play a key role in cellular differentiation. The significance of Notch1 during
thymocyte development is well characterized, but the function of Notch2 is poorly …

The generation of a peripheral T-cell pool is essential for normal immune system function.
CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a …

We have recently reported that Notch 1, a member of the Notch multigene family, is essential
for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated …

Establishing an effective epidermal barrier requires a series of coordinated molecular events
involving keratinocytes (KCs) within a stratified epithelium. Epidermal maturation depends …

The Notch signaling pathway plays a key role at several stages of T-lymphocyte
differentiation. However, it remained unclear whether signals induced by the Notch ligand …

Hematopoietic stem cells (HSCs) maintain hematopoiesis by giving rise to all types of blood
cells. Recent reports suggest that HSCs also possess the potential to generate …