Notch-1 signaling is essential for lymphoid progenitors to undergo T cell commitment, but
the mechanism has not been defined. Here we show that thymocytes ectopically expressing …

Notch signaling regulates cell fate decisions during development. Recent experiments
suggest that Notch signaling is essential for initial commitment to the T cell lineage and may …

The ability of the mucosal immune system to distinguish between harmful and harmless
antigens is essential for mounting protective immune responses and preventing the …

In mice, activation of the Notch pathway in T cells by antigen-presenting cells
overexpressing Notch ligands favors differentiation of regulatory T lymphocytes responsible …

Notch participates in diverse cell fate decisions throughout embryonic development and
postnatal life. Members of the NF-κB/Rel family of transcription factors are involved in the …

Thymic dendritic cells (DCs) form a discrete subset of bone marrow (BM)-derived cells, the
function of which is to mediate negative selection of autoreactive thymocytes. The …

Tec family kinases are implicated in T cell receptor (TCR) signaling, and combined mutation
of inducible T cell kinase (Itk) and resting lymphocyte kinase (Rlk)/Txk in mice dramatically …

Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …

Importance Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown
etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD …

Regulatory T cells participate in immunologic homeostasis by active suppression of
inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 …