Notch in Invertebrate Development. Notch proteins are highly conserved transmembrane
receptors that are involved in cell fate regulation in invertebrates (1). While Notch receptors …

The molecular events triggered by MHC recognition and how they lead to the emergence of
mature CD4 and CD8 lineage thymocytes are not yet understood. To address these …

Fig. 1 The influence of Notch1 activation on stem cell self-renewal and on the fate of stem
cell progeny, as demonstrated by events in the T-cell pathway. It also induces stem cell …

CSL is the primary target of the Notch signaling pathway in mammalian cells. It is a DNA
binding protein that generally represses transcription in the absence of Notch signaling and …

As reviewed in part I, the inflammatory bowel diseases (IBD) 4—Crohn disease (CD) and
ulcerative colitis (UC)—are in large part determined by genetic predispositions. The …

Notch is heavily involved in T cell lineage commitment... or is it? New data indicates that
neither CD4 nor CD8 cell maturation is Notch1-dependent, whereas Notch1 is critical for …

Stem cell antigen 2 (SCA2) is a Ly-6 family member whose function is largely unknown. To
characterize biological properties and tissue distribution of chicken SCA2, SCA2 was …

There is ample evidence that the inflammatory bowel diseases (IBD)-Crohn's disease (CD)
and ulcerative colitis (UC)-are in large part determined by genetic predispositions. The …

Transgenic mice expressing hK10 under the keratin K5 promoter display several alterations
in the epidermis including decreased cell proliferation, and reduced susceptibility to tumor …