The catalyst-directed divergent synthesis, commonly termed as “divergent catalysis”, has
emerged as a promising technique as it allows chartering of structurally distinct products …

While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

This two‐part Review examines how automation has contributed to different aspects of
discovery in the chemical sciences. In this first part, we describe a classification for …

Skeletal rearrangement that changes the connectivity of the molecule via cleavage and
reorganization of carbon–carbon bonds is a fundamental and powerful strategy in complex …

All pharmaceutical products contain organic molecules; the source may be a natural product
or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry …

Medicinal chemistry plays a fundamental and underlying role in chemical biology,
pharmacology, and medicine to discover safe and efficacious drugs. Small molecule …

Scaffold diversity is a key feature of a compound library and plays a pivotal role in its
success in biological screening. Therefore, it is highly desirable to develop efficient …

The exploration of the complex chemical diversity of bicyclo [n. 1.1] alkanes and their use as
benzene bioisosteres has garnered significant attention over the past two decades …

S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in
metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group …

Polycyclic scaffolds are omnipresent in natural products and drugs, and the synthetic
strategies and methods toward construction of these scaffolds are of particular importance …