The gut–brain axis and its relation to Parkinson's disease: a review

EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

The function of gut microbiota in immune-related neurological disorders: A review

P Sittipo, J Choi, S Lee, YK Lee - Journal of Neuroinflammation, 2022 - Springer
This review provides an overview of the importance of microbiota in the regulation of gut–
brain communication in immune-related neurological disorders. The gastrointestinal (GI) …

GLP-1a: going beyond traditional use

LF Laurindo, SM Barbalho, EL Guiguer… - International Journal of …, 2022 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …

Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

S Hassamal - Frontiers in psychiatry, 2023 - frontiersin.org
In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

Berberine ameliorates depression‐like behavior in CUMS mice by activating TPH1 and inhibiting IDO1‐associated with tryptophan metabolism

PY Ge, SY Qu, S Ni, ZY Yao, YY Qi… - Phytotherapy …, 2023 - Wiley Online Library
Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the
gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild …

GLP-1 receptor agonists and related mental health issues; insights from a range of social media platforms using a mixed-methods approach

D Arillotta, G Floresta, A Guirguis, JM Corkery… - Brain Sciences, 2023 - mdpi.com
The emergence of glucagon-like peptide-1 receptor agonists (GLP-1 RAs; semaglutide and
others) now promises effective, non-invasive treatment of obesity for individuals with and …

Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor

J Helmstädter, K Keppeler, L Küster… - British journal of …, 2022 - Wiley Online Library
Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus
patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists …

The therapeutic potential of GLP‐1 receptor biased agonism

B Jones - British Journal of Pharmacology, 2022 - Wiley Online Library
Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are effective treatments for type 2
diabetes as they stimulate insulin release and promote weight loss through appetite …

Development of dementia in type 2 diabetes patients: mechanisms of insulin resistance and antidiabetic drug development

DD Singh, AA Shati, MY Alfaifi, SEI Elbehairi, I Han… - Cells, 2022 - mdpi.com
Dementia is reported to be common in those with type 2 diabetes mellitus. Type 2 diabetes
contributes to common molecular mechanisms and an underlying pathology with dementia …

Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression

J Detka, K Głombik - Pharmacological Reports, 2021 - Springer
Depression is a highly prevalent mood disorder and one of the major health concerns in
modern society. Moreover, it is characterized by a high prevalence of coexistence with many …