A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

Although long-read single-cell RNA isoform sequencing (scISO-Seq) can reveal alternative
RNA splicing in individual cells, it suffers from a low read throughput. Here, we introduce HIT …

Multiple sclerosis is a chronic inflammatory disease of the central nervous system.
Astrocytes are heterogeneous glial cells that are resident in the central nervous system and …

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …

Single-cell RNA-seq makes it possible to characterize the transcriptomes of cell types across
different conditions and to identify their transcriptional signatures via differential analysis …

In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing
(RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the …

Cancer transcriptomes frequently exhibit RNA dysregulation. As the resulting aberrant
transcripts may be translated into cancer-specific proteins, there is growing interest in …

Full-length SMART-seq single-cell RNA sequencing can be used to measure gene
expression at isoform resolution, making possible the identification of specific isoform …