[HTML][HTML] Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data
High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene
expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing …
expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing …
[HTML][HTML] New technologies to study helminth development and host-parasite interactions
How parasites develop and survive, and how they stimulate or modulate host immune
responses are important in understanding disease pathology and for the design of new …
responses are important in understanding disease pathology and for the design of new …
RNA splicing programs define tissue compartments and cell types at single-cell resolution
The extent splicing is regulated at single-cell resolution has remained controversial due to
both available data and methods to interpret it. We apply the SpliZ, a new statistical …
both available data and methods to interpret it. We apply the SpliZ, a new statistical …
RNA-Bloom enables reference-free and reference-guided sequence assembly for single-cell transcriptomes
Despite the rapid advance in single-cell RNA sequencing (scRNA-seq) technologies within
the last decade, single-cell transcriptome analysis workflows have primarily used gene …
the last decade, single-cell transcriptome analysis workflows have primarily used gene …
[HTML][HTML] Obstacles to detecting isoforms using full-length scRNA-seq data
J Westoby, P Artemov, M Hemberg, A Ferguson-Smith - Genome Biology, 2020 - Springer
Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual
to see more than one isoform being produced from a gene in a single cell, even when …
to see more than one isoform being produced from a gene in a single cell, even when …
[HTML][HTML] Identification of cell barcodes from long-read single-cell RNA-seq with BLAZE
Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA
isoforms in individual cells. However, long-read scRNA-seq using the Oxford Nanopore …
isoforms in individual cells. However, long-read scRNA-seq using the Oxford Nanopore …
Pan-cancer analysis of clinical relevance of alternative splicing events in 31 human cancers
Alternative splicing represents a critical posttranscriptional regulation of gene expression,
which contributes to the protein complexity and mRNA processing. Defects of alternative …
which contributes to the protein complexity and mRNA processing. Defects of alternative …
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution
The molecular causes and mechanisms of neurodegenerative diseases remain poorly
understood. A growing number of single-cell studies have implicated various neural, glial …
understood. A growing number of single-cell studies have implicated various neural, glial …
Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
[HTML][HTML] Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data
R Herbrechter, N Hube, R Buchholz… - Cellular and Molecular Life …, 2021 - Springer
Ionotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …