[HTML][HTML] Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation
Y Kawachi, Y Fujishima, H Nishizawa, T Nakamura… - JCI insight, 2021 - ncbi.nlm.nih.gov
Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and
xanthine to uric acid, respectively. However, the underlying mechanisms of increased …
xanthine to uric acid, respectively. However, the underlying mechanisms of increased …
Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia
K Kario, M Nishizawa, M Kiuchi… - The Journal of …, 2021 - Wiley Online Library
Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even
when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) …
when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) …
Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication
M Furuhashi, Y Higashiura, M Koyama… - Hypertension …, 2021 - nature.com
Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation
in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR …
in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR …
[HTML][HTML] Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice
K Takahashi, H Mizukami, S Osonoi… - Neurobiology of …, 2021 - Elsevier
Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy.
According to recent evidence, the modulation of macrophage polarization in peripheral …
According to recent evidence, the modulation of macrophage polarization in peripheral …
[HTML][HTML] The effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, on arterial stiffness in hyperuricemic patients with liver dysfunction: a sub-analysis of …
Y Fujishima, H Nishizawa, Y Kawachi, T Nakamura… - Biomedicines, 2023 - mdpi.com
Background: The effects of uric acid (UA)-lowering therapy with xanthine oxidoreductase
(XOR) inhibitors on the development of cardiovascular diseases remain controversial …
(XOR) inhibitors on the development of cardiovascular diseases remain controversial …
[HTML][HTML] Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice
T Nakamura, M Nampei, T Murase, E Satoh… - Nutrition & …, 2021 - nature.com
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as
diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR …
diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR …
[HTML][HTML] Effects of Xanthine Oxidoreductase Inhibitors on Reactive Oxygen Species Produced In Vitro from Xanthine Oxidase
M Noda, C Kikuchi, R Tarui, T Nakamura, T Murase… - BPB Reports, 2023 - jstage.jst.go.jp
Xanthine oxidase (XO) produces reactive oxygen species (ROS) and has been associated
with vascular endothelial dysfunction. While the effects of xanthine oxidoreductase (XOR) …
with vascular endothelial dysfunction. While the effects of xanthine oxidoreductase (XOR) …
Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model
HF Al-Saedi, MR Al-Notazy… - Archives of Razi …, 2022 - archrazi.areeo.ac.ir
Dermatitis, like inflammation, is a group of common dermatological symptoms and may be
associated with systemic and skin diseases. The objective of the current study is to evaluate …
associated with systemic and skin diseases. The objective of the current study is to evaluate …