Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Although painful stimuli elicit defensive responses including escape behavior for survival,
starved animals often prioritize feeding over escape even in a noxious environment. This …

Pain, although unpleasant, is an essential warning mechanism against injury and damage
of the organism. An intricate network of specialised sensors and transmission systems …

Chronic pain conditions are unmet medical needs, since the available drugs, opioids, non-
steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide …

Transient receptor potential (TRP) ion channels are involved in the surveillance or
regulation of the acid-base balance. Here, we demonstrate that weak carbonic acids …

The transient receptor vanilloid 1 (TRPV1) is a non-selective ion channel, which is activated
by several chemical ligands and heat. We have previously shown that activation of TRPV1 …

Cardiovascular diseases (CVDs) have been recognized as the leading cause of premature
mortality and morbidity worldwide despite significant advances in therapeutics. Inflammation …

Purpose: To reveal the role of cold-sensing transient receptor potential melastatin 8
(TRPM8) channels in corneal epithelial wound healing. Methods: Cold sensitivity, tear …

TRPV1 represents a non-selective transient receptor potential cation channel found not only
in sensory neurons, but also in motor nerve endings and in skeletal muscle fibers. However …