The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

A mutual relationship exists between immune activation and mechanisms of thrombus
formation. In particular, elements of the innate immune response such as the complement …

Background—Inflammatory processes have been identified as key mediators of the
deleterious effects of ischemia/reperfusion in ST-segment–elevation myocardial infarction …

Cardiovascular disease remains the main cause of death worldwide. For this reason,
strategies for the primary prevention of atherosclerosis and atherosclerosis-related …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

The complement system is a versatile part of our immune system. Various intersection points
of complement with other cells and molecules of the immune response are well described …

Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can
lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF …

Heart diseases are common and significant contributors to worldwide mortality and
morbidity. During recent years complement mediated inflammation has been shown to be an …

Abstract Apabetalone (RVX-208) is an epigenetic regulator developed to treat
cardiovascular disease (CVD) that targets BET proteins. Through transcriptional regulation …

Cardiovascular diseases remain to be the leading cause of death in Western societies.
Despite major findings in vascular biology that lead to a better understanding of the …