Strategies to optimize clinical genetic diagnostic pathways by combining both targeted and
next-generation sequencing are discussed. In addition to improved genetic counseling …

Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

Premature fusion of the cranial sutures (craniosynostosis), affecting 1 in 2000 newborns, is
treated surgically in infancy to prevent adverse neurologic outcomes. To identify mutations …

The brain originates relatively early in development from differentiated ectoderm that forms a
hollow tube and takes on an exceedingly complex shape with development. The skull is …

Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …

BACKGROUND Craniosynostosis is a condition in which 2 or more of the skull bones fuse
prematurely. The spectrum of the disorder most commonly involves the closure of a single …

Craniosynostosis, the premature fusion of one or more cranial sutures of the skull, provides
a paradigm for investigating the interplay of genetic and environmental factors leading to …

Craniosynostosis is a condition of complex etiology that always involves the premature
fusion of one or multiple cranial sutures and includes various anomalies of the soft and hard …

This article provides an overview of the diagnosis and management of infants with
craniosynostosis. This review also incorporates some of the treatment philosophies followed …

Craniosynostosis, the premature ossification of one or more skull sutures, is a clinically and
genetically heterogeneous congenital anomaly affecting approximately one in 2,500 live …