Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

Pioneered by Huisgen in the 1960s, 1 the 1, 3-dipolar cycloaddition reaction between
acetylenes and azides was brought back into focus by Sharpless and others2 when they …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

Triple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low
survival. Long non-coding RNAs (lncRNAs) play critical roles in tumor progression. Here, we …

DNA structure is a critical element in determining its function. The DNA molecule is capable
of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that
can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a …

Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of
gene structure and function, and in understanding chromosome dynamics. It also offers a …

Synthetic oligonucleotides (ONs) are being investigated for various therapeutic and
diagnostic applications. The interest in ONs arises because of their capability to cause …